Reference of 84199-61-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 84199-61-1, name is 3-Acetyl-2-bromopyridine, molecular formula is C7H6BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a 200 mL round bottle flash was added sodium tert-butoxide (1.3equiv), followed by the addition of 50mL anhydrous THF, the mixture was stirred until all base was dissolved. Methyltriphenylphosphonium iodide (1.2equiv) was added in one port and the heterogeneous solution was stirred at rt for 30min. Pyridyl ketones (1.0equiv) were added slowly and the mixture was stirred at rt overnight. The mixture was quenched with water and extracted with ether twice. The combined organic layer was dried (MgSO4) and filtered, concentrated to provide some oil mixed with powder. The crude material was then distilled by Kugelrohr apparatus at 10mBar with temperature ranging from 50 to 100C to afford the product as colorless liquid. Characterization of unreported 1d, 1f is listed below:
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 84199-61-1, 3-Acetyl-2-bromopyridine.
Reference:
Article; Lian, Yajing; Burford, Kristen; Londregan, Allyn T.; Tetrahedron; vol. 71; 50; (2015); p. 9509 – 9514;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem