New learning discoveries about 73455-13-7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73455-13-7, its application will become more common.

Electric Literature of 73455-13-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 73455-13-7, name is 4,5-Dichloropicolinic acid. A new synthetic method of this compound is introduced below.

A mixture of 4,5-dichloropicolinic acid (100 mg, 521 imol; CAN 73455-13-7), 1-cyclopropyl-2- (5-methyl-i ,2,4-oxadiazol-3-yl)propan-2-amine hydrochloride (136 mg, 625imol; CAN 1415900-39-8), 2-bromo-i-ethylpyridinium tetrafluoroborate (284 mg, 885imol) and N,N-diisopropyl ethyl amine (212 mg, 281 iL) in dioxane (0.8 mL) was stirredfor 14 h at 80 C, poured onto ice / brine (1 x 25mL) and extracted with EtOAc (2 x 25mL). The combined extracts were washed with ice water / brine (25 mL), dried overNa2SO4 and filtered. The filtrate was brought to dryness and the residue was purified by column chromatography (silica gel, 10 g, heptane / ethyl acetate) to obtain the title compound (120 mg, 65%) as colorless liquid, LC-MS: 355.2 [MH?i.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73455-13-7, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FREI, Beat; GOBBI, Luca; GRETHER, Uwe; RICKLIN, Fabienne; ROEVER, Stephan; ROGERS-EVANS, Mark; ROMBACH, Didier; (49 pag.)WO2018/234284; (2018); A1;,
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