Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 717843-56-6, name is 3-Bromo-2-methoxy-5-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 3-Bromo-2-methoxy-5-methylpyridine
-Bromo-5-bromomethyl-2-methoxy-pyridine To a solution of the product from step 131.4 (3.0 g, 14.7 mmol), was added NBS (3.1 g, 17.6 mmol) and AIBN (121 mg, 0.7 mmol) and the mixture was stirred at 80C for 1 h. H20 and CH2CI2 were added and the phases were separated. The organic layer was dried (MgS04), filtered and concentrated. The crude product was purified by flash chromatography (heptane/EtOAc, 95:5? 0:100). tR: 1.10 min (LC-MS 2).
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Reference:
Patent; NOVARTIS AG; FURET, Pascal; GUAGNANO, Vito; HOLZER, Philipp; KALLEN, Joerg; LIAO, Lv; MAH, Robert; MAO, Liang; MASUYA, Keiichi; SCHLAPBACH, Achim; STUTZ, Stefan; VAUPEL, Andrea; WO2013/111105; (2013); A1;,
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