As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 67938-76-5, name is (5-Chloropyridin-2-yl)methanamine, molecular formula is C6H7ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: (5-Chloropyridin-2-yl)methanamine
To a mixture of A-l (2.00 g, 14.03 mmol) in THF (30 mL) was added TFAA (4.42 g, 21.05 mmol), then the mixture was stirred at 20 °C for 16 hours. The mixture was concentrated and the resulting residue was diluted with 0 (50 mL), and extracted with EtOAc (100 mL x 2). The combined organic phase was washed with sat. Na2C03 (30 mL), water (50 mL) and brine (50 mL), dried over Na2S04, filtered and concentrated to give A-2 (3.10 g, 12.99 mmol) as a solid. 1H NMR (400MHz, CDC13) = 8.54 (d, 1H), 7.85 – 7.60 (m, 2H), 7.25 (d, 1H), 4.63 (d, 2H).
With the rapid development of chemical substances, we look forward to future research findings about 67938-76-5.
Reference:
Patent; PRAXIS PRECISION MEDICINES, INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (141 pag.)WO2018/98491; (2018); A1;,
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