Adding a certain compound to certain chemical reactions, such as: 887266-57-1, 3-Fluoro-2-hydrazinylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 3-Fluoro-2-hydrazinylpyridine, blongs to pyridine-derivatives compound. name: 3-Fluoro-2-hydrazinylpyridine
Under argon, a solution of methyl 2-{3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2- hydroxypropyl]-4,5-dihydro-1H-l,2,4-triazol-1-yl}ethanimidate (Example 2A, 200 mg, 528 muiotaetaomicron) in THF (2.0 ml) was treated at 0C with N,N-diisopropylethylamine (280 mu, 1.6 mmol) and (2R)- l-chloro-1-oxopropan-2-yl acetate (73 mu, 580 muiotaetaomicron) and stirred at 0C for 30 min. 3-Fluoro-2- hydrazinylpyridine (73.8 mg, 581 muiotaetaomicron) was then added and the resulting mixture was stirred overnight at room temperature and evaporated. The residue was purified by preparative HPLC (Method 4) affording 195 mg (65% of th.) of the title compound.LC-MS (Method 1): Rt = 1.01 min; MS (ESIpos): m/z = 570 [M+H]+-NMR (400 MHz, DMSO-d6) delta [ppm]: 8.46 (br. d, 1H), 8.14 (m, 1H), 7.86-7.53 (m, 5H), 6.89 (d, 1H), 5.93 (q, 1H), 5.12 (m, 2H), 4.30 (m, 1H), 4.11-3.74 (m, 2H), 1.79 (s, 3H), 1.59 (d, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,887266-57-1, 3-Fluoro-2-hydrazinylpyridine, and friends who are interested can also refer to it.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; COLLIN-KROePELIN, Marie-Pierre; KOLKHOF, Peter; NEUBAUER, Thomas; FUeRSTNER, Chantal; POOK, Elisabeth; TINEL, Hanna; SCHMECK, Carsten; WASNAIRE, Pierre; SCHIRMER, Heiko; LUSTIG, Klemens; GRIEBENOW, Nils; (195 pag.)WO2019/81302; (2019); A1;,
Pyridine – Wikipedia,
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