Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1211532-15-8, name is 6-Methoxy-5-(trifluoromethyl)nicotinic acid. A new synthetic method of this compound is introduced below., Recommanded Product: 1211532-15-8
(5-bromopyridin-2-yl) ((2S) -2- (4-chlorophenyl) piperazin- 1 -yl) methanone hydrochloride (300 mg)6-methoxy-5- (trifluoromethyl) nicotinic acid (180 mg),HATU (0.4 g),A mixture of triethylamine (0.2 ml) and DMF (3 ml)And the mixture was stirred at room temperature for 2 hours.The mixture was extracted with ethyl acetate and water. The obtained organic layer was washed with saturated brine, dried over magnesium sulfate and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane / ethyl acetate) to give the title compound (338 mg).
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Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; MIZOJIRI, RYO; CARY, DOUGLAS ROBERT; HIRAYAMA, TAKAHARU; ITO, MASAHIRO; TANAKA, TOSHIO; IMAEDA, YASUHIRO; SASAKI, SHIGEKAZU; TAKAMI, KAZUAKI; FUKUDA, KOICHIRO; KAMAURA, MASAHIRO; MORISHITA, NAO; (133 pag.)JP2017/222626; (2017); A;,
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