Introduction of a new synthetic route about 1083197-78-7

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1083197-78-7, 4-(Trifluoromethyl)nicotinaldehyde, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 1083197-78-7, 4-(Trifluoromethyl)nicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 4-(Trifluoromethyl)nicotinaldehyde, blongs to pyridine-derivatives compound. Recommanded Product: 4-(Trifluoromethyl)nicotinaldehyde

General procedure: A solution of lithium hydroxide (0.8 mg, 0.03 mmol) and 2′-methoxyacetophenone (26 mg, 0.157 mmol) in absolute methanol (1.5 mL) was stirred at room temperature for 15 min. To the resulting mixture was added a solution of 2-(trifluoromethyl)-3-pyridinecarboxaldehyde (6a, 28 mg, 0.16 mmol) in absolute methanol (15 mL). The reaction was stirred overnight at room temperature (approx. 18 h). The reaction was then concentrated on a rotary evaporator and the resulting oily residue purified by chromatography on silica gel using a gradient of 0-100% ethyl acetate in hexane to provide the desired product (17 mg, 35%) as a light yellow waxy solid. Prepared using the general method from lithium hydroxide (3 mg, 0.125 mmol)), 2′-methoxyacetophenone (94 mg, 0.625 mmol)) and 4-trifluoromethyl-3-pyridinecarboxaldehyde (6c, 111 mg, 0.635 mmol) in absolute methanol (final reaction volume = 4 mL). The reaction mixture was purified by chromatography on silica gel (gradient of 0-100% ethyl acetate in hexane) to give the desired product as a yellow oil (104 mg, 54%). 1H NMR (CDCl3) delta 8.99 (s, 1H), 8.70 (d, J = 5.5 Hz, 1H), 7.81 (dd, J = 15.8, 2.0 Hz, 1H), 7.63 (dd, J = 7.6, 1.8 Hz, 1H), 7.51 (d, J = 5.5 Hz, 1H), 7.46 (dt, J = 8.4, 1.8 Hz, 1H), 7.42 (d, J = 15.8 Hz, 1H), 7.00 (t, J = 7.6 Hz, 1H), 6.94 (d, J = 8.4 Hz, 1H), 3.94 (s, 3H). 13C NMR (CDCl3) delta 191.2, 158.5, 151.4, 150.7, 149.4, 136.1, 134.2, 133.9, 132.4, 130.9, 129.1, 128.2, 121.7, 119.5, 111.6, 55.6. HRMS (FAB): calcd C16H12F3NO2 + H = 308.0898, found 308.0900.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1083197-78-7, 4-(Trifluoromethyl)nicotinaldehyde, and friends who are interested can also refer to it.

Reference:
Article; Lounsbury, Nicole; Mateo, George; Jones, Brielle; Papaiahgari, Srinivas; Thimmulappa, Rajash K.; Teijaro, Christiana; Gordon, John; Korzekwa, Kenneth; Ye, Min; Allaway, Graham; Abou-Gharbia, Magid; Biswal, Shyam; Childers, Wayne; Bioorganic and Medicinal Chemistry; vol. 23; 17; (2015); p. 5352 – 5359;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem