In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18699-87-1, name is 2-Methyl-3-nitropyridine, the common compound, a new synthetic route is introduced below. Recommanded Product: 18699-87-1
Step 2: 2-bromomethyl-3-nitropyridine; 2,2′-azobis(isobutyronitrile) (2.7 g, 16.4 mmol) was added to a solution of2-methyl-3-nitropyridine (12.97 g, 92.6 mmol) prepared in Step 1 and N- bromo-succinimide (23.06 g, 130 mmol) in carbon tetrachloride (100 ml) and then the reactionmixtue was refluxed for 3 days. The reaction mixture was cooled to room temperatureand then concentrated under reduced pressure. The resulting residue was diluted withethyl acetate (100 ml) and then washed with a saturated sodium bicarbonate solutionand a saturated sodium thiosulfate solution. The organic layer was dried on anhydrousmagnesium sulfate and then purified with silica gel column chromatography(dichloromethane/n-hexane=2/l, v/v) to give 7.5 g of the titled compound as brown oil. lH-NMR(400MHz, CDC1) 5 8.82(d, 1H), 8.39(d, 1H), 7.56(t, 1H), 5.07(s, 2H)
The synthetic route of 18699-87-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; YUHAN CORPORATION; JANG, Sun-Young; WO2006/25716; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem