Adding a certain compound to certain chemical reactions, such as: 26163-03-1, 3-Bromo-5-chloropyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 26163-03-1, blongs to pyridine-derivatives compound. Application In Synthesis of 3-Bromo-5-chloropyridin-2-amine
a sobthDn of 2-amiao-Thlznio-&cIueolopydin? (10.0 g, 4S.2 mmol7 Ark Phmm iii Nfl dim?thyl.fcamumide (2] niL) was ailed DMF-DMA (17.2 g, 145 nutol) anl the nthrthre was sbned13] C fca abc?at 18 K The mixbare was cooled aat evapcnted to thyness. To an ice cooled Hn sob fioiiofthebrcwiisolid iiiMeOH (JO mL) ardpyridim (7.8QniL, %nutiol)was added hthor,r1anthie-o-sulforth td (73g, 675 nmnol). TIE rac&iwas allowed to wanr to thciat 25anl stind fbr about 13 K The nuethr? was evapra±ed and the solid iesithie was dissohd in DCM (150 mL) aid washel with ;aturated o1±uaubicaabointe (10 niL), water (20] niL) ard biine (10 nL). The oigai& nuethre was filtered though a Eiote phase sepantc to renrn iesi&ial wateraiid evapcnted to thyrs to give ?-Ch1 [LZ4]1rio1o[L5-a]pth2e as an cnie soli4 whck was used iii th n?xttep witlout fint1r purificaiiou.. (.l g, 64% nude): ?H NMR (CDC1.)i5 2155(d, 1 1.3Hz, 1H), 239 (s, 1H), 7SJ (, 1 1.7Hz, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,26163-03-1, its application will become more common.
Reference:
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; FRIEDMAN, Michael M.; COX, Philip; FRANK, Kristine E.; HOEMANN, Michael Z.; OSUMA, Augustine; WILSON, Noel S.; XU, Xiangdong; WO2015/157955; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem