Related Products of 1060811-62-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1060811-62-2, name is 4,6-Dichloronicotinaldehyde. A new synthetic method of this compound is introduced below.
To a stirred solution of 2,6-difluoro-3,5-dimethoxyaniline (9.03 g, 47.7 mmol), sodium triacetoxyborohydride (38.0 g, 180 mmol) in methylene chloride (60 mL)/ trifluoroacetic acid (30. mL), 4,6-dichloronicotinaldehyde (8.00 g, 45.5 mmol) was added in small portions at room temperature. After 1 hour, the volatiles were removed in vacuo and saturated aqueous NaHCO3 (200 mL) was added. The resulting mixture was extracted withDCM (3 xl 50 mL). The organic layers were combined, dried over Na2SO4, and concentrated. The residue was purified on silica gel (eluting with 0 to 0-40percent EtOAc in hexanes) to affordthe desired product (15.0 g). LC-MS calculated for C14H13C12F2N202 [M+H] mlz: 349.0; found 349.1.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1060811-62-2, 4,6-Dichloronicotinaldehyde, and friends who are interested can also refer to it.
Reference:
Patent; INCYTE CORPORATION; LU, Liang; SHEN, Bo; SOKOLSKY, Alexander; WANG, Xiaozhao; WU, Liangxing; YAO, Wenqing; YE, Yingda; (217 pag.)WO2016/134320; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem