Adding a certain compound to certain chemical reactions, such as: 89364-04-5, 3-Bromo-4-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 89364-04-5, blongs to pyridine-derivatives compound. Product Details of 89364-04-5
To a well stirred solution of 3-bromo-4-nitro pyridine (12.Og, 54.794 mmol) in methanol (120 mL) was bubbled dry hydrochloride gas at about 0-50C for about 1-2-hours. The reaction mixture was then stirred at ambient temperature for about 6-8 hours. The solvent was evaporated under reduced pressure, the residue obtained was diluted with 20% aqueous solution of sodium hydroxide (100 mL) and extracted with dichloromethane (3 x 100 mL). The combined organic layer was washed with water and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give 3-bromo-4-chloro-pyridine-N- oxide as an off-white crystalline solid. Yield: >97%, m.p.: 147-1490C.IR (KBr):- 3436, 3078, 3054, 1449, 1414, 1274, 1243, 1150, 1042, 900, 670 cm’1. 1H NMR (300 MHz, DMSOd6): d 7.71 (d, IH, J= 6.6 Hz), 8.24 (d, IH, J= 5.1 Hz), 8.75 (s, IH).
The synthetic route of 89364-04-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLENMARK PHARMACEUTICALS, S.A.; WO2008/142542; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem