Electric Literature of 147619-40-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.147619-40-7, name is 5-Chloro-4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile, molecular formula is C7H5ClN2O2, molecular weight is 184.58, as common compound, the synthetic route is as follows.
Add in 100ml three-necked flask5-chloro-4-methoxy-3-cyano-2- (1H) pyridone,48percent hydrobromic acid 40 ml,Heated to 70-80 ° C dissolved,Reaction for about 1-2 hours,Generate a lot of solid,TLC monitors the reaction to the end.The reaction system was filtered,Wash the filter cake with a small amount of purified water.The filter cake was dissolved with 100 ml of a 3percent aqueous solution of potassium carbonate,And then pre-mixed with 4N hydrochloric acid to adjust the pH to 3-4,Precipitation of a large number of solid,After stirring for 0.5 hours,The filter cake was beaten with 5 ml of methanol and 50 ml of dichloromethane,After stirring for 0.5 hours,Filter cake in 55-60 blast drying,Get class white solid,That is, structural analogues E,Weight 4.3g, yield 50.4percent.
The chemical industry reduces the impact on the environment during synthesis 147619-40-7, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Nanjing Zhengda Tianqing Pharmaceutical Co., Ltd.; Zheng, Likang; Guo, Xuan; Zhang, Ping; Zhang, Linlin; Chai, Yuzhu; Xu, Dan; Yang, Zhimin; Tian, Zhoushan; (14 pag.)CN104592102; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem