Related Products of 6318-51-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6318-51-0, name is (4-Chlorophenyl)(pyridin-2-yl)methanone. A new synthetic method of this compound is introduced below.
0.2 g of (4-chlorophenyl) (2-pyridyl) methanone was dissolved in 2 mL of hydrogen peroxide (mass concentration of 30% aqueous solution) 1.0 mL of acetic acid was added and the reaction was heated to 85 C. for 12 h. The progress of the reaction was monitored by TLC until the reaction was complete. The mixture was saturated with sodium bicarbonate, extracted with dichloromethane, washed, and the organic phases were combined, dried over anhydrous sodium sulfate, filtered, Removal of the solvent gave 0.21 g of a white solid in 95% yield.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6318-51-0, (4-Chlorophenyl)(pyridin-2-yl)methanone, and friends who are interested can also refer to it.
Reference:
Patent; Yichang Renfu Pharmaceutical Co., Ltd.; China Three Gorges University; Fu Yigang; Lv Jinliang; Zhou Haifeng; Wang Baigui; Cao Lu; Zheng Huazhang; Tian Luanyuan; Li Shiqun; Li Lie; Du Wentao; (13 pag.)CN106938995; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem