Application of 60781-83-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 60781-83-1, name is 4-Phenylpyridin-2-amine. A new synthetic method of this compound is introduced below.
EXAMPLE 8 2,3-Dihydro-6-phenylcyclopenta[d]pyrido[1,2-a]pyrimidin-10(1H)-one A mixture of 17.0 g. of 2-amino-4-phenylpyridine and 31.2 g. of ethyl cyclopentane-2-carboxylate is heated at an internal temperature of 160-165 for 4 hours. During this time ethanol distils from the reaction mixture and is collected in a Dean-Stark trap. During the 4 hours of heating, about 5.5 ml of distillate is collected. When the reaction mixture is allowed to cool, a crystalline solid separates. The mixture is cooled to 0 and the solid filtered. Recrystallization from cyclohexane gives 24.7 g. of 2,3-dihydro-6-phenylcyclopenta[d]pyrido[1,2-a]pyrimidin-10(1H)-one.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60781-83-1, its application will become more common.
Reference:
Patent; E. R. Squibb & Sons, Inc.; US3965100; (1976); A;,
Pyridine – Wikipedia,
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