Reference of 1159812-31-3, Adding some certain compound to certain chemical reactions, such as: 1159812-31-3, name is 7-Bromo-2-methyl-[1,2,4]triazolo[1,5-a]pyridine,molecular formula is C7H6BrN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1159812-31-3.
To a solution of 7-bromo-2-methyl-[l,2,4]triazolo[1,5-a]pyridine (4.40 g, 20.7 mmol) and diphenylmethanimine (5.64 g, 31.1 mmol) in l,4-dioxane (60 mL) were added Pd2(dba)3 (952.2 mg, 1.04 mmol), BINAP (1.29 g, 2.07 mmol) and Cs2C03 (13.52 g, 41.50 mmol). The mixture was stirred at 100 C for 4 hours under N2 atmosphere, and concentrated in vacuo. The residue was diluted with water (200 mL) and DCM (100 mL), and the separated aqueous layer was extracted with DCM (100 mL c 2). The combined organic layers were washed with water (100 mL c 2), and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/PE (v/v) = 1/5 to 1/2) to give the title compound as brown oil (6.48 g, yield 100%).MS (ESI, pos. ion) m/z: 313.1 [M+H]+.
According to the analysis of related databases, 1159812-31-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Minxiong; PENG, Ju; LI, Xiaobo; ZHANG, Tao; HU, Haiyang; CHEN, Wuhong; BAI, Changlin; KE, Donghua; CHEN, Peng; (281 pag.)WO2019/99311; (2019); A1;,
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