Introduction of a new synthetic route about 884494-51-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,884494-51-3, its application will become more common.

Electric Literature of 884494-51-3 ,Some common heterocyclic compound, 884494-51-3, molecular formula is C6H3FINO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A suspension of 2-fluoro-4-iodonicotinic acid (896 mg, 3356 mumol) in 6M hydrochloric acid (13423 mul, 80540 mumol) was heated at 100 0C. After 5 min, the reaction became a solution, and then a precipitate appeared. The reaction mixture was stirred 60 min at 100 0C and then cooled to room temperature. Filtration afforded 2- hydroxy-4-iodonicotinic acid (710 mg, 2679 mumol, 80% yield). MS (ESI pos. ion) m/z: 248(M+H-H2O). Calc’d exact mass for C6H4INO3: 265.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,884494-51-3, its application will become more common.

Reference:
Patent; Amgen Inc.; WO2006/116713; (2006); A1;,
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