Adding a certain compound to certain chemical reactions, such as: 1032943-43-3, 4-Bromo-1H-pyrazolo[3,4-c]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 4-Bromo-1H-pyrazolo[3,4-c]pyridine, blongs to pyridine-derivatives compound. Safety of 4-Bromo-1H-pyrazolo[3,4-c]pyridine
To a stirred solution of 4-bromo-1H-pyrazolo[3,4-c]pyridine (0.320 g, 1.62 mmol) inDMF (10 mL)were addedZn(CN)2(0.190 g, 1.62 mmol) andZnCl2(0.110 g, 0.808 mmol). The resulting reaction mixture was degassed with nitrogen for 5 minutes and tetrakis(triphenylphosphine)palladium(0) (0.373 g, 0.323 mmol) was added and again degassed with nitrogen for 5 minutes. The reaction mixture was heated in a sealed tube at100 C for 10 h. The reaction mixture was cooled and concentrated under reduced pressure, diluted with water (40 mL) and extracted with EtOAc (2 x 20 mL). The combined organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting residue was purified by CombiFlash (Redisep-24 g, 70 % EtOAc/n-hexanes), to obtain Intermediate 1-10 (0.14 g, 60 %). ?HNIVIR (400 MHz, DMSO-d6) ppm 8.50 (s, 1 H), 8.75 (s, 1 H), 9.38 (s, 1 H), 14.32 (br, s,1 H). LCMS (methodE), retention time 0.647 mi [M+H] 145.0.
The synthetic route of 1032943-43-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; GUNAGA, Prashantha; RICHTER, Jeremy; YADAV, Navnath Dnyanoba; PANDA, Manoranjan; GODESI, Sreenivasulu; (132 pag.)WO2017/184662; (2017); A1;,
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