Reference of 71670-70-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 71670-70-7, name is 2-(Chloromethyl)-5-methylpyridine hydrochloride. A new synthetic method of this compound is introduced below.
[Step 2] Production of 2-[(5-methylpyridin-2-yl)methoxy]-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline To 4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinolin-2-ol (20 mg), 2-(chloromethyl)-5-methylpyridine hydrochloride (32 mg) and silver(I) carbonate (73 mg) was added DMF (1 mL), and the mixture was stirred at 100C for 3 hours. After the reaction mixture was allowed to return to room temperature, diluted with ethyl acetate, filtered through Celite, and the filtrate was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography to give the title compound (7.5 mg) as colorless oil. [MS (ESI) m/z 332.1 (M+H)+]
At the same time, in my other blogs, there are other synthetic methods of this type of compound,71670-70-7, 2-(Chloromethyl)-5-methylpyridine hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; Nippon Shinyaku Co., Ltd.; TSUJI, Takashi; SHIRAI, Masaaki; EP2891656; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem