Analyzing the synthesis route of 6-Chloro-5-nitronicotinic acid

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7477-10-3, 6-Chloro-5-nitronicotinic acid, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 7477-10-3, 6-Chloro-5-nitronicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H3ClN2O4, blongs to pyridine-derivatives compound. Formula: C6H3ClN2O4

General procedure: A solution of compound 4 and different primary and secondary amines were stirred at rt for 1h, followed by extraction with EtOAc. The extract was then washed with 1N HCl, water, and brine, dried over Na2SO4, and evaporated in vacuo. The residue was purified by column chromatography (hexane/EtOAc=2:1) to give product 6 as a solid.4.2.4.4 6-[4-(2-Methoxyphenyl)piperazin-1-yl]-5-nitronicotinic acid (6d) Procedure A was used with compound 5 (100 mg, 0.5 mmol) and 1-(2-methoxyphenyl)piperazine (193 mg, 1.0 mmol) to afford product 6d as a yellow solid (138 mg, 77%). 1H NMR (300 MHz, CDCl3) delta: 8.92 (d, J = 1.8 Hz, 1H), 8.74 (d, J = 1.8 Hz, 1H). 7.08-7.03 (m, 1H), 6.94-6.89 (m, 3H), 3.90 (s, 3H), 3.82 (t, J = 4.8 Hz, 4H), 3.18 (t, J = 4.8 Hz, 4H). ESI-MS: m/z (357, MH-).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7477-10-3, 6-Chloro-5-nitronicotinic acid, and friends who are interested can also refer to it.

Reference:
Article; Zhao, Chao; Yang, Su Hui; Khadka, Daulat Bikram; Jin, Yifeng; Lee, Kyung-Tae; Cho, Won-Jea; Bioorganic and Medicinal Chemistry; vol. 23; 5; (2015); p. 985 – 995;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem