Application of 940943-37-3 , The common heterocyclic compound, 940943-37-3, name is S-(2-(6-(4-(3-(Dimethylamino)propoxy)phenylsulfonamido)pyridin-3-yl)-2-oxoethyl) ethanethioate, molecular formula is C20H25N3O5S2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
[0202] Into 0.3088 g of Compound 1 was added 2 mL of methanol and 1.0 molar equivalent of hydrochloric acid (0.5 M in methanol, made from concentrated aqueous HCl solution) at approximately 60 0C. An additional 0.5 mL of methanol was added and the solution left to stir until only a small amount of solid remained. The sample was filtered through a 0.2 micron nylon filter. Seeds of HCl A were added and dissolved immediately upon addition. The solution was allowed to cool slowly to ambient temperature. Additional seeds (HCl A) were added and a light yellow precipitation followed. The solids were isolated by vacuum filtration and stored in a P205 desiccator (0.2373 g; yield 71%, based on unsolvated weight).
The synthetic route of 940943-37-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KALYPSYS, INC.; WO2008/73733; (2008); A1;,
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