Related Products of 73112-16-0, Adding some certain compound to certain chemical reactions, such as: 73112-16-0, name is 2,6-Dibromo-4-methylpyridine,molecular formula is C6H5Br2N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 73112-16-0.
To a solution of 2,6-dibromo-4-methyl-pyridine (5.1 g, 20.4 mmol) and 4-[l-(4-Methoxy-benzyl)-l H-pyrazol-4-yl]-pyridin-2-ylamine (5.2 g, 18.6 mmol) in dioxane (150 mL) was added sodium tert-butoxide (1.96 g, 20.4 mmol) and then l, l ‘-bis(di-t- butylphosphino)ferrocene palladium dichloride (1.2 g, cat.) was added. The mixture was degassed by nitrogen for 3 times and then refluxed for 15h. The mixture was partitioned between water and EtOAc, and the organic layers were washed with brine, dried over sodium sulfate and concentrated under reduced pressure. The residue was purified via flash- chromatography on silica gel (30 % EtOAc in petroleum ether) to give (6-Bromo-4-methyl- pyridin-2-yl)- {4-[l-(4-methoxy-benzyl) -lH-pyrazol-4-yl]-pyridin-2-yl}-amine (3.0 g, yield 36.1 %) as a light yellow solid. MS ESI calc’d. For: C22 H20BrN5O [M + H]+ 450, found 450.
According to the analysis of related databases, 73112-16-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ANDRESEN, Brian, M.; ANTHONY, Neville, J.; MILLER, Thomas, A.; WO2014/74422; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem