Related Products of 1231930-13-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1231930-13-4, name is 3-Bromo-2-methyl-6-nitropyridine. A new synthetic method of this compound is introduced below.
2-(4-methyl-1H-imidazol-1-yl)pyridin-4-ol (200 mg, 1.14 mmol) was dissolved in N,N-dimethylformamide (5 mL), and then 3-bromo-2-methyl-6-nitropyridine (250 mg, 1.14 mmol), and potassium carbonate (472 g, 3.42 mmol) were added. The reaction solution was stirred at 90 C. for 16 hrs, then poured into water (200 mL), and then extracted twice with ethyl acetate (50 mL*2). The organic phases were combined and washed once with a brine (100 mL), dried over sodium sulfate, then concentrated, and separated by column chromatography (eluent: petroleum etherpetroleum ether/ethyl acetate (4:6)) to obtain 2-methyl-3-((2-(4-methyl-1H-imidazol-1-yl)pyridin-4-yl)oxy)-6-nitropyridine (60 mg, yield 17%). MS m/z (ESI): 311 [M+H]+
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1231930-13-4, 3-Bromo-2-methyl-6-nitropyridine, and friends who are interested can also refer to it.
Reference:
Patent; Abbisko Therapeutics Co., Ltd.; ZHAO, Baowei; ZHANG, Mingming; YU, Hongping; YANG, Shuqun; CHEN, Zhui; XU, Yaochang; US2020/71302; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem