Related Products of 884495-22-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 884495-22-1 as follows.
To 5-bromo-2-fluoropyridin-3-amine (400 mg, 2.094 mmol) was added DMSO (2.5 ml) and morpholine (912 mg, 10.47 mmol). The reaction mixture was stirred at 110- 115 C for 40 hours. The reaction was cooled to room temperature and 200 ml of ethyl acetate was added. The mixture was washed with saturated sodium bicarbonate (2x), water (lx), brine (lx), dried with sodium sulfate, filtered and concentrated to yield 535 mg of the title compound as free base which was used without further purification.LCMS (m/z): 258.0/260.0 (MH+), retention time = 0.52 mm.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,884495-22-1, its application will become more common.
Reference:
Patent; NOVARTIS AG; ANTONIOS-MCCREA, William, R.; BARSANTI, Paul, A.; HU, Cheng; JIN, Xianming; MARTIN, Eric, J.; PAN, Yue; PFISTER, Keith, B.; SENDZIK, Martin; SUTTON, James; WAN, Lifeng; WO2012/66070; (2012); A1;,
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