Synthetic Route of 1231930-13-4, Adding some certain compound to certain chemical reactions, such as: 1231930-13-4, name is 3-Bromo-2-methyl-6-nitropyridine,molecular formula is C6H5BrN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1231930-13-4.
A mixture of Example C6 (2 g, 5.15 mmol), Example A6 (1.053 g, 3.96 mmol) and Pd(PPh3)4 (0.229 g, 0.198 mmol) in toluene (20 mL), sparged with Ar and heated at 105 C. overnight. The mixture was cooled to RT, treated 10% KF (aq) and EtOAc and stirred at RT for 2 h. The solids were removed via filtration through diatomaceous earth, washed with EtOAc and the filtrate was washed with satd. NaHCO3, then brine, dried over Na2SO4, concentrated to dryness and purified via silica gel chromatography (EtOAc/Hex) to afford 2-methyl-5-(4-((2-methyl-6-nitropyridin-3-yl)oxy)pyridin-2-yl)thiazole (1.06 g, 81%). 1H NMR (400 MHz, DMSO-d6): delta 8.50 (d, J=5.7 Hz, 1H), 8.34 (s, 1H), 8.24 (d, J=8.7 Hz, 1H), 7.88 (d, J=8.7 Hz, 1H), 7.72 (d, J=2.4 Hz, 1H), 7.02 (dd, J=5.7, 2.4 Hz, 1H), 2.65 (s, 3H), 2.50 (s, 3H); MS (ESI) m/z: 329.1 (M+H+).
According to the analysis of related databases, 1231930-13-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Deciphera Pharmaceuticals, LLC; Flynn, Daniel L.; Kaufman, Michael D.; Samarakoon, Thiwanka; Caldwell, Timothy Malcolm; Vogeti, Lakshminarayana; Ahn, YuMi; Patt, William C.; Yates, Karen M.; US2014/315917; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem