With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.135450-23-6, name is 6-(Chloromethyl)-2-cyanopyridine, molecular formula is C7H5ClN2, molecular weight is 152.58, as common compound, the synthetic route is as follows.category: pyridine-derivatives
General procedure: Reference Example 24 6-(5-Methoxy-2-phenylindol-1-ylmethyl)pyridine-2-carbonitrile [0267] To a solution of 5-methoxy-2-phenyl-1H-indole (200 mg) in N,N-dimethylformamide (5 mL) was added sodium hydride (dispersed in liquid paraffin, 50% or more, 45 mg) under ice-cooling. This mixture was stirred for 30 minutes at room temperature. Subsequently, 6-chloromethylpyridine-2-carbonitrile (216 mg) was added thereto, followed by stirring at 80C overnight. Water was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluting solvent: ethyl acetate-hexane) to obtain the title compound (228 mg). [0268] 1H-NMR (DMSO-d6) delta ppm: 3.77 (3H, s), 5.55 (2H, s), 6.55-6.65 (1H, m), 6.77 (1H, dd, J = 2.4, 8.8 Hz), 6.91 (1H, dd, J = 1.5, 7.4 Hz), 7.13 (1H, d, J = 2.4 Hz), 7.26 (1H, d, J = 8.8 Hz), 7.35-7.55 (5H, m), 7.85-7.95 (2H, m).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,135450-23-6, 6-(Chloromethyl)-2-cyanopyridine, and friends who are interested can also refer to it.
Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; Kyorin Pharmaceutical Co., Ltd.; TATANI, Kazuya; KONDO, Atsushi; KONDO, Tatsuhiro; KAWAMURA, Naohiro; SETO. Shigeki; KOHNO, Yasushi; EP2669271; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem