Related Products of 1111637-94-5, Adding some certain compound to certain chemical reactions, such as: 1111637-94-5, name is 5-Bromo-3-methyl-1H-pyrrolo[2,3-b]pyridine,molecular formula is C8H7BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1111637-94-5.
NaH (60 in oil, 284 mg, 7.11 mmol) is added to an ice-cooled sol. of 5-bromo-3-methyl-7-azaindole (1.0 g, 4.74 mmol) in THF (12 mL). The mixture is stirred at rt for 15 min, then cooled again to 0 C. Mel (1.19 mL, 19 mmol) is added, and the resulting mixture is stirred at 0 C for 10 min, then at rt overnight. Water is slowly added, followed by MgSC^. The mixture is filtered, and the solvents are removed under reduced pressure. Purification of the residue by automated FC (Combiflash, column 40 g, flow 40 mL/min, EtOAc / heptane 0: 100?20:80) yields the title product. LC-MS: tR = 0.87 min, MH+ = 226.94 (conditions 3).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1111637-94-5, 5-Bromo-3-methyl-1H-pyrrolo[2,3-b]pyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; SIEGRIST, Romain; HEIDMANN, Bibia; STAMM, Simon; GATFIELD, John; BEZENCON, Olivier; WO2015/186056; (2015); A1;,
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