Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 77618-99-6, name is 2-Amino-5-(methylthio)pyridine. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Amino-5-(methylthio)pyridine
Step 4 To 112 muL (1.05 mmol) of 4-fluorobenzaldehyde and 147 mg (1.05 mmol) of 2-amino-5-methylthio-pyridine, dissolved in 6 mL dichloromethane was added 334 mg (1.57 mmol) sodium triacetoxyborohydride. The reaction mixture was stirred at room temperature for 4 h. The mixture was then partitioned between ethyl acetate and brine, dried over MgSO4 and concentrated. Purification by column chromatography, eluding with ethyl acetate/hexane, provided 185 mg product, 2-[(4-fluorobenzyl)amino]-pyridin-5-yl methyl sulfide, pure by 1H NMR.
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Reference:
Patent; Krauss, Nancy Elisabeth; Mirzadegan, Taraneh; Smith, David Bernard; Walker, Keith Adrian; US2002/52349; (2002); A1;,
Pyridine – Wikipedia,
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