Application of 2002-04-2, Adding some certain compound to certain chemical reactions, such as: 2002-04-2, name is 5-(Pyridin-4-yl)-1,3,4-thiadiazol-2-amine,molecular formula is C7H6N4S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2002-04-2.
To a suspension of 6-chloronicotinoyl chloride hydrochloride (0.985 g, 5.6 mmol, 1 eq.) in pyridine (10 rriL), cooled in an ice bath was added 5-(pyridin-4-yl)-l,3,4-thiadiazol-2- amine (1.0 g, 5.6 mmol, 1 eq.). The mixture was allowed to warm to ambient temperature and stirred for 16 hours. The resultant solid was filtered and washed successively with saturated aqueous sodium hydrogen carbonate and water before being dried in vacuo to give 6-chloro-N-(5-(pyridin-4-yl)-l ,3,4-thiadiazol-2-yl)nicotinamide as a white solid (1.61 g, 91 % yield). NMR (400 MHz, DMSO) 13.72 (1H, s), 9.10 (1H, d, J=2.3 Hz), 8.77 – 8.75 (2H, m), 8.50 (1H, dd, J=2.5, 8.6 Hz), 7.98 – 7.96 (2H, m), 7.77 (1H, d, J=8.6 Hz).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2002-04-2, 5-(Pyridin-4-yl)-1,3,4-thiadiazol-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GENKYOTEX SA; MACHIN, Peter; SHARPE, Andrew; LOCK, Christopher James; CHAMBERS, Mark S; HODGES, Alastair; ALLEN, Vivienne; ELLARD, John M; (189 pag.)WO2016/98005; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem