Reference of 3222-56-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3222-56-8, name is 2-Methylnicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.
29) 2-methylnicotinamideTo a solution of 2-methylnicotinic acid (0.537 mg, 3.9 mmol) in 20 mL of DMF at 0 0C was added HATU (1.56 g, 4.1 mmol) followed by the dropwise addition of DIPEA (0.72 ml, 4.1 mmol). NH3(g) was then bubbled into the solution for 15 mins. The reaction was o allowed to stir overnight. The resulting paste was filtered and rinsed with cold DMF and discarded. The mother liquor was concentrated and purified by normal phase chromatography using CH2Cl2/7 N NH3 in MeOH: 93/7 as eluent. Yielded a white solid (405 mg, 76 %). IH NMR (400 MHz, CHLOROFORM-D) delta ppm 1.34 (s, 9 H), 1.36 (d, J=6.64 Hz, 3 H), 2.56 (s, 3 H), 4.32 – 4.40 (m, 1 H), 7.15 – 7.19 (m, J=8.20 Hz, 1 H), 7.68 (d, J=8.20 Hz, s I H)
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3222-56-8, 2-Methylnicotinic acid.
Reference:
Patent; ASTRAZENECA AB; WO2007/73303; (2007); A2;,
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