Reference of 86604-79-7 ,Some common heterocyclic compound, 86604-79-7, molecular formula is C8H10N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step 4; [00286] Jifj-2,3,5-Dimethyl-4-nitropyridine-l -oxide: A dry heavy-walled teflon screw cap glass tube equipped with a magnetic stirrer was charged with 2,3,5-trimethyl-4- nitropyridine-1 -oxide (5 g, 27.5 mmol), potassium carbonate (3.8 g, 27.5 mmol) and deuterium oxide (30 mL) under nitrogen. The apparatus was sealed and the mixture was placed in an oil bath at about 15O0C for about 2 hours. The reaction was cooled to ambient temperature, and sodium chloride (1Og) and brine (50 mL) were added. The title product, 4.2 g of a yellow solid with identical TLC behavior as the starting material (Rf = 0.3 in 10% methanol-DCM), was isolated using standard extractive work up. The above process was repeated to afford 3.25 g of product that had deuterium incorporation of 98.1% as determined by GC-MS analysis. Yield: 65%. GC-MS: [M]+: 192 (81.6%, 2,3,5-trimethyl-4- nitropyridine-1 -oxide-dio), 191 (18.3%, 2,3,5-trimethyl-4-nitropyridine-l-oxide-d9). Step 4[00294] fi(m-2,3,5-Dimethyl-4-nitropyridine-1 -oxide: The title compound was made by following the procedure set forth in Example 1, step 4.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,86604-79-7, its application will become more common.
Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; WO2008/127640; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem