Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89415-54-3, name is 5-Bromo-N2-methylpyridine-2,3-diamine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 5-Bromo-N2-methylpyridine-2,3-diamine
Production Example 42A mixture of 5-bromo-N2-methylpyridin-2 , 3-diamine (0.70 g) , 2-ethylsulfanylbenzoic acid (0.66 g) , SC (0.80 g) , HOBt (23 mg) , and pyridine (20 ml) was stirred under reflux at 120 C for 30 minutes. After the reaction mixture was allowed to stand overnight, the mixture was stirred under reflux at 120 C for 9.5 hours again. Into the reaction mixture cooled to room temperature, water was poured under ice-cooling, and extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over sodium sulfate, and concentrated under reduced pressure. A mixture of the resulting residue and acetic anhydride (7 ml) was stirred under reflux at 140 C for 1 hour. Aqueous sodium hydroxide solution was added to the reaction mixture cooled to room temperature to neutralize, and extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over sodium sulfate, and concentrated under reduced pressure. The resulting residue was subjected to silica gel column chromatography to give 0.60 g of 6-bromo-2- (2- ethylsulfanylphenyl ) -3-methyl-3H-imidazo [ 4 , 5-b] pyridine (hereinafter referred to as Present Compound 42) .Present Compound 421H-NMR (CDC13) delta : 8.47 (lH,d), 8.22 (lH,d), 7.54-7 (2H,m), 7.45-7.42 (lH,m), 7.37-7.32 (lH,m), 3.71 (3H, 2.86 (2H, q ) , 1.23 (3H,t)
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Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; TAKYO, Hayato; TAKAHASHI, Masaki; TANABE, Takamasa; NOKURA, Yoshihiko; ITO, Mai; IWATA, Atsushi; WO2012/86848; (2012); A1;,
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