Application of 10128-72-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10128-72-0, name is Methyl 3-hydroxyisonicotinate, molecular formula is C7H7NO3, molecular weight is 153.14, as common compound, the synthetic route is as follows.
[0166] To a solution of chloride (200 mg, 1.0 mmol, 1.0 eq), and phenol (153 mg, 1.0 mmol, 1.0 eq) in DMF (15 mL) was added K2C03 (414 mg, 3.0 nimol, 3.0 eq) and the reaction mixture was heated at 8 0-90 C for 5 h. Solvent was removed and the residue was purified by column chromatography (EtOAc/ MeOH) to give the alkylation product. MS: exact mass calculated for C15H13N303, 283.10; m/z found, 284 [M+H]+.
The chemical industry reduces the impact on the environment during synthesis 10128-72-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley; WO2013/102145; (2013); A1;,
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