Electric Literature of 823-39-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 823-39-2, name is 3,4-Dimethylpyridin-2-amine. A new synthetic method of this compound is introduced below.
G. (L)-N-Boc-6-methanesulfonylnorleucine allyl ester (11b) As an alternative approach, to a cooled (0 C. bath) solution of (L)-N-Boc-6-hydroxynorleucine allyl ester (10) from E above (80 mg, 0.28 mmol), triethyl amine (80 muL, 0.57 mmol), dimethyl amino pyridine (DMAP) (cat) in anhydrous CH2 Cl2 (1 mL) under N2 was added methane sulfonyl chloride (27 muL, 0.34 mmol). The contents were warmed (rt) and the mixture was concentrated under reduced pressure and purified by flash chromatography (silica gel; EtOAc/hexane, (1:19, v/v)) to provide a light yellow oil identified as (L)-N-Boc-6-methanesulfonylnorleucine allyl ester (11 b) (81 mg, 79%): TLC (SiO2, EtOAc/hexane (1:1, v/v)) Rf =0.36; 1 H NMR (360 MHz, CDCl3) delta5.98-5.84 (m, 1 H), 5.38-5.24 (m, 2 H), 5.08-4.96 (m, 1 H), 4.70-4.58 (m, 2 H), 4.38-4.26 (m, 1 H), 4.21 (t, J=6.4 Hz, 2 H), 2.99 (s, 3 H), 1.95-1.35 (m, 15 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,823-39-2, its application will become more common.
Reference:
Patent; Keystone Biomedical, Inc.; US5952492; (1999); A;,
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