Introduction of a new synthetic route about 5-Chloro-3-fluoro-2-nitropyridine

The synthetic route of 1064783-29-4 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1064783-29-4, 5-Chloro-3-fluoro-2-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C5H2ClFN2O2, blongs to pyridine-derivatives compound. Computed Properties of C5H2ClFN2O2

5-chloro-3-fluoro-2-nitropyridine (510 mg), 1-amino-2-methylpropan-2-ol (283 mg)A mixture of diisopropylethylamine (1.1 mL) and NMP (3 mL) was stirred at room temperature for 15 h. Water was added to the reaction solution, and the resulting solid was collected by filtration and washed with water and hexane to prepare compound 11 (370 mg).

The synthetic route of 1064783-29-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; Komiya, Masafumi; Mizushima, Shingo; Iwamoto, Kohei; Urashima, Kuniko; (48 pag.)JP2018/154562; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem