Application of 53277-47-7

At the same time, in my other blogs, there are other synthetic methods of this type of compound,53277-47-7, Methyl 2-chloro-6-methylnicotinate, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.53277-47-7, name is Methyl 2-chloro-6-methylnicotinate, molecular formula is C8H8ClNO2, molecular weight is 185.61, as common compound, the synthetic route is as follows.Quality Control of Methyl 2-chloro-6-methylnicotinate

Methyl 6-bromomethyl-2-chloronicotinate Methyl 2-chloro-6-methyinicofinate from Example F1 (5.70 g, 30.8 mmol) was reacted following the method of Example of A1. The product was purified by flash chromatography on silica (eluant EtOAC:pet. ether 20:80); yield 4.8 g (58%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,53277-47-7, Methyl 2-chloro-6-methylnicotinate, and friends who are interested can also refer to it.

Reference:
Patent; Ashworth, Doreen; Pitt, Gary R W; Hudson, Peter; Yea, Christopher; Franklin, Richard J; Semple, Graeme; Jenkins, David Paul; US2004/38962; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem