Application of 86873-60-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 86873-60-1, name is 5-Chloro-2-picolinic acid. A new synthetic method of this compound is introduced below.
5-Chloro-2-pyridine carboxylic acid (48.5 mg, 0.31 mmol) was added to a stirred sol. of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (155 mg, 0.34 mmol) in MeOH (10 mL). After 5 mm, intermediate compound 1-16 (100 mg, 0.28 mmol) in MeOH (5 mL) was added at 0 C. The mixture was stirred at rt for 16 h. Themixture was treated with sat. aq. Na2CO3 sol. and extracted with DCM. The organic phase was separated, dried (MgSO4), filtered and the solvents evaporated in vacuo. The crude product was purified by flash column chromatography (silica; DCM-MeOH (10:1(25% NH3), v/v) in DCM 0/100 to 40/60). The desired fractions were collected and the solvents evaporated in vacuo. The solid was triturated with DIPE and filtered to yield compound 8 as a solid (69 mg, 50%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,86873-60-1, 5-Chloro-2-picolinic acid, and friends who are interested can also refer to it.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; OEHLRICH, Daniel; GIJSEN, Henricus, Jacobus, Maria; WO2014/198851; (2014); A1;,
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