Synthetic Route of 955372-86-8 ,Some common heterocyclic compound, 955372-86-8, molecular formula is C6H3BrFNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
I ntermediate 7: 3-Bromo-5-( 2-ftuoro-phenylamino)-isonicotinic acid; Lithium bis(trimethylsilyl)amide (54.6 ml_, 1.0 M in THF, 54.6 mmol) was added to a solution of 2-fluoro aniline (3.5 mL, 36.4 mmol) in THF (100 ml_) at -78 0C. The resulting solution was for 1 h at -780C. S-Bromo-delta-fluoro-isonicotinic acid (1) (4.0 g, 18.2 mmol) was added as a solid, and the reaction solution was stirred for 48 h at room temperature. The reaction solution was concentrated via rotary evaporation; diluted with satd. NaHCO3, and washed with EtOAc. The aqueous solution was acidified with concentrated HCI. The resulting precipitate was filtered, washed with H2O, and dried under vacuum to afford the desired product (4.2 g, 74%) as a yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 955372-86-8, 3-Bromo-5-fluoroisonicotinic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.; WO2007/123936; (2007); A1;,
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