Adding a certain compound to certain chemical reactions, such as: 1033810-70-6, [1,2,4]Triazolo[1,5-a]pyridin-7-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1033810-70-6, blongs to pyridine-derivatives compound. Recommanded Product: 1033810-70-6
The mixture of l-fluoro-2-methyl-4-nitrobenzene (96 mg, 0.617 mmol), [l,2,4]triazolo[l,5-a]pyridin-7-ol (100 mg, 0.740 mmol) aid cesium carbonate (482 mg, 1.48 mmol) in dimethyl sulfoxide (2.5 ml) was stirred at 80 C for 3 hr. The resulting mixture was poured into ice water and the precipitate was filtered and dried using blowing nitrogen gas to give 4-([l,2,4]triazolo[l,5-a]pyridin-7-yloxy)-3-methylaniline as a brown solid (145 mg, 87 %).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1033810-70-6, [1,2,4]Triazolo[1,5-a]pyridin-7-ol, and friends who are interested can also refer to it.
Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; GRAY, Nathanael S.; JANG, Jaebong; JANNE, Pasi; SON, Jieun; (116 pag.)WO2019/241715; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem