As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13534-97-9, name is 6-Bromopyridin-3-amine, molecular formula is C5H5BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 6-Bromopyridin-3-amine
Step 3: ethyl 4-(5-amino-2,3′-bipyridin-6′-yloxy)cyclohexanecarboxylate (B-33)To a solution of ethyl 4-(5-(4,4,5s5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyridin-2- yloxy)cyclohexanecarboxylate (300 mg, 0.799 mmol) and 5-amino-2-bromopyridine (160 mg, 0.924 mmol) in 1,4 dioxane:3/40 (3:1, 20 mL) was addedtetrakis(triphenylphosphine)palladium(0) (194 mg, 0.168 mmol) and Na2C03 (267 mg, 2.52 mmol). The reaction mixture was heated to reflux and stirred for 15 h. The solution was filtered through celite, concentrated and purified by ISCO to yield ethyl 4-(5-amino-2,3′- bipyridin-6′-yloxy)cyclohexanecarboxylate as a brown oil (191 mg, 70percent yield 1 :1 trans is ratio). MS (M+l): 342.
With the rapid development of chemical substances, we look forward to future research findings about 13534-97-9.
Reference:
Patent; SCHERING CORPORATION; TING, Pauline, C.; LEE, Joe, F.; ASLANIAN, Robert, G.; WO2011/31628; (2011); A1;,
Pyridine – Wikipedia,
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