As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 630120-99-9, name is 5-(Benzyloxy)-2-bromopyridine, molecular formula is C12H10BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 5-(Benzyloxy)-2-bromopyridine
Palladium acetate (0.43 g, 1.89 mmol), l,l’-bis(diphenylphosphino)ferrocene(2.10 g, 3.79 mmol), and triethylamine (11. 1 ml, 80.0 mmol) were added to a methanol solution (200 ml) of 5-(benzyloxy)-2-bromopyridine (10.0 g, 37.8 mmol) under carbon monoxide atmosphere, this mixture was stirred for 2 days at 9O0C. This reaction solution was cooled to room temperature, followed by concentrating this solvent under reduced pressure and purifying the obtained residue by silica gel column chromatography (Flash cartridge 65M, hexane:ethyl acetate=l :1) to obtain methyl 5-(benzyloxy)pyridin-2-carboxylate (7.48 g, yield: 81%) as an ecru solid.
With the rapid development of chemical substances, we look forward to future research findings about 630120-99-9.
Reference:
Patent; BANYU PHARMACEUTICAL CO.,LTD.; IINO, Tomoharu; ASAI, Masanori; OHNO, Akio; IF2; ISHIKAWA, Makoto; OHTAKE, Norikazu; WO2010/24110; (2010); A1;,
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