Reference of 33252-28-7 , The common heterocyclic compound, 33252-28-7, name is 6-Chloronicotinonitrile, molecular formula is C6H3ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
90.3 g (1.8 mol) of hydrazine hydrate are added to 25.0 g (180.4 mmol) of 6-chloronicotinonitrile, and the mixture is stirred at a bath temperature of 100 C. for 15 min. The reaction mixture is cooled to RT, diluted with water and stirred at RT for 30 min. The precipitate formed is filtered off, the filter residue is washed with water and the crystals are air-dried for 24 h and recrystallized once from ethyl acetate. Yield: 18.7 g (77% of theory) LC-MS (Method 1): Rt=0.51 min; MS (ESIpos): m/z=135 [M+H]+; 1H-NMR (400 MHz, DMSO-d6)=8.58 (s, 1H), 8.33 (s, 1H), 7.74 (d, 1H), 6.76 (br. s, 1H), 4.42 (s, 2H).
The synthetic route of 33252-28-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Bayer Scherring Pharma Aktiengellschaft; US2010/93803; (2010); A1;,
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