Reference of 26956-43-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 26956-43-4, name is Furo[3,2-c]pyridin-4(5H)-one, molecular formula is C7H5NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a mixture of furo [3 2-c] pyridin-4 (5H) -one (5 g 37.0 mmol) in MeCN (50 mL) was added a solution of NBS (8.56 g 48.1 mmol) in MeCN at 0 over 10 min. The resulting suspension was stirred at 0 for 1 h and warmed to rt for 10 min. Water (250 mL) and saturated aqueous NaHCO3(10 mL) ware added to the mixture. Off-white solids ware collected by filtration and dried to afford 7-bromofuro [3 2-c] pyridin-4 (5H) -one (1.5 g 5.96 mmol 16.10 yield) 1HNMR(400 MHz CD3OD) delta 7.82 (d J 2.0 Hz 1H) 7.51 (s 1H) 7.05 (d J 2.4 Hz 1H) ES-LCMS m/z 214.0 215.9 (M+H)
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 26956-43-4, Furo[3,2-c]pyridin-4(5H)-one.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R & D COMPANY LIMITED; CHEUNG, Mui; DEMARTINO, Michael P.; EIDAM, Hilary Schenck; GUAN, Huiping Amy; QIN, Donghui; WU, Chengde; GONG, Zhen; YANG, Haiying; YU, Haiyu; ZHANG, Zhiliu; (391 pag.)WO2016/37578; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem