Related Products of 72093-04-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72093-04-0, name is 3-Chloro-4-methylpyridine, molecular formula is C6H6ClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
a, under the protection of nitrogen,(0.194 mmol) of [Ir(COD)Cl] 2 (1,5-cyclooctadiene ruthenium chloride dimer) was sequentially added to the reaction flask,R-(+)-1,1′-binaphthyl-2,2′-diphenylphosphine (0.192 mmol), 150 ml of toluene, stirred at room temperature for 20 min, then added potassium iodide 20.59 g (0.0962 mol) and3-Chloro-4-methylpyrene 12.27g (0.0962mol), the reaction flask was placed in a stainless steel autoclave, replaced with hydrogen three times, and finally rushed to the required hydrogen pressure of 600 psi, reacted at room temperature for 12 h, slowly Release hydrogen, dilute the reaction system with 150 mL of dichloromethane, add 150 mL of saturated sodium carbonateThe solution was stirred for 15 min, the organic layer was separated, and then aqueous layer was extracted with dichloromethane (3×150mL). The organic layer was combined and dried over Na2SO4 to remove solvent to give compound III 17.89 g, yield 99.2%, HPLC purity 99.96%. The ee value is 95%.
According to the analysis of related databases, 72093-04-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shandong Luoxin Pharmaceutical Group Hengxin Pharmaceutical Co., Ltd.; Shandong Luoxin Pharmaceutical Group Co., Ltd.; Shandong Yuxin Pharmaceutical Co., Ltd.; Li Zhibin; Qin Lili; Li Xuanxuan; (9 pag.)CN108794491; (2018); A;,
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