Reference of 184368-74-9 ,Some common heterocyclic compound, 184368-74-9, molecular formula is C12H19NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 1 -(tert-butyl)4-methyl-3 ,6-dihydropyridine- 1 ,4(2H)-dicarboxy-late (1.7 g, 7.3 mmol) in DCM (20 ml) at -78 C was added DIBAL-H (1.0 M in toluene,10.5 ml, 10.5 mmol) followed by stirring at RT for 16 h. The reaction was cooled to 0C and quenched with water and extracted with DCM. The organic layer was dried,filtered and concentrated under reduced pressure to give 1.5 g of the title compound asgreenish viscous liquid. LC-MS: mlz 214 (M+H) +.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 184368-74-9, 1-tert-Butyl 4-methyl 5,6-dihydropyridine-1,4(2H)-dicarboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ORION CORPORATION; DIN BELLE, David; MAeKELAe, Mikko; PASSINIEMI, Mikko; PIETIKAeINEN, Pekka; RUMMAKKO, Petteri; TIAINEN, Eija; VAISMAA, Matti; WOHLFAHRT, Gerd; (254 pag.)WO2018/115591; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem