Adding a certain compound to certain chemical reactions, such as: 103577-66-8, (3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C9H10F3NO2, blongs to pyridine-derivatives compound. COA of Formula: C9H10F3NO2
Ph3PO (43.78 g, 157.5 mmol) was dissolved in toluene (100 mL) in a 500 mL three-necked flask and BTC(14.84 g, 50 mmol) was dissolved in toluene (60 mL) and placed in a 150 mL constant pressure dropping funnel,BTC was added dropwise at room temperature, and the temperature was raised to 60 ° C after completion of the dropwise addition.After incubation for 4 hours, 2-hydroxymethyl-3-methyl-4- (2,2,2-trifluoroethoxy) pyridine(33.15 g, 150 mmol) was dissolved in 75 mL of toluene and added at 40 ° C to precipitate a white solid. After the reaction was carried out for 2 hours, the reaction was stopped and the white solid was obtained by filtration to dryness 2-chloromethyl-3-methyl-4- (2,2,2-trifluoroethoxy) pyridine hydrochloride 40.01 g, product yield 97percent
The synthetic route of 103577-66-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhejiang University of Technology; Hainan Weikang Pharmaceutical (Qianshan) Co., Ltd.; Weng Yiyi; Su Weike; Wang Jincan; Wang Ningqing; Zhong Da; Zhu Zhixin; (27 pag.)CN107011252; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem