Reference of 4434-13-3 ,Some common heterocyclic compound, 4434-13-3, molecular formula is C7H7NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a stirred solution of 5-methylpicolinic acid (2.5 g, 18 mmol) in 50C12 (10 mL) was slowly added DMF (21.3 mg, 3 mmol). The resulting solution was heated to 72 oC for 12h. After cooling to room temperature, the mixture was diluted with toluene and concentrated to near dryness in vacuo. MeOH was added to the obtained oily residue. The contents were stirred for 2 h at 30 oC. After filtration, aq.15% Na2CO3 was added to the filter cake to adjust its pH to 7, and then washed with cold MeOH to afford the title compound (220 mg). MS (ES) m/z 186 (M+H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4434-13-3, 5-Methylpicolinic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CORVUS PHARMACEUTICALS, INC.; HUDSON, Ryan; BEAUSOLEIL, Anne-Marie; (616 pag.)WO2018/89261; (2018); A2;,
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