As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1839-17-4, name is N4-Methylpyridine-3,4-diamine, molecular formula is C6H9N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C6H9N3
(d) N-(4-methylamino-3-pyridyl)-N’-cyclohexylthiourea Cyclohexyl isothiocyanate (1.09 ml, 7.71 mmol) was added to a solution of 3-amino-4-methylaminopyridine (950 mg, 7.71 mmol) in DMF (5 ml), and the mixture was stirred at room temperature for 1 hour and at 120 C. for 3 hours. After removal of the solvent, the residue was subjected to silica gel column chromatography (eluent: chloroform_methanol=10:1 (v/v)) and recrystallization to purify it, thereby obtaining 98 mg of the intended product as flesh-colored crystals. m.p.: >250 C. IR (KBr): 3500-3000, 2920, 1600 cm-1 1 H-NMR (CDCl3) delta ppm: 1.0-2.1 (10H, m), 2.89 (3H, d, J=4.0 Hz), 4.1-4.4 (1H, m), 4.93 (1H, d, J=4.0 Hz), 5.72 (1H, d, J=6.0 Hz), 6.56 (1H, d, J=6.0 Hz), 7.65 (1H, s), 8.10 (1H, s), 8.26 (1H, d, J=6.0 Hz) 13 C-NMR (CDCl3) delta ppm: 24.5, 25.1, 28.7, 32.2, 53.8, 105.2, 118.0, 147.4, 149.0, 151.7, 179.9
With the rapid development of chemical substances, we look forward to future research findings about 1839-17-4.
Reference:
Patent; The Green Cross Corporation; US5262415; (1993); A;,
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