Related Products of 709652-82-4 , The common heterocyclic compound, 709652-82-4, name is 2-Amino-5-bromonicotinonitrile, molecular formula is C6H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A propionitrile (15 mL) solution of 2-amino-5-bromo-nicotinonitrile (198 mg, 1 mmol), N-methyl-N-(1-methyl-1H-indol-2-ylmethyl)-acrylamide (457 mg, 2 mmol) and DIISOPROPYL-ETHYLAMINE (523 UL, 3 mmol) was purged with Argon for 10 min. Pd (OAc) 2 (23 mg, 0.1 mmol) and P (o-Tol) 3 (61 mg, 0.2 mmol) was added and the Argon purge was repeated. The mixture was heated to 100 C and stirred for 6 hr under Argon. Upon cooling, solvents were removed under vacuo and the residue was purified by Flash chromatography (silica, 2% MEOH in CH2CL2). The purified free base was converted to its HCl salt by addition of HCl (1 mL, 1 mmol, 1M in ether). The salt was washed with ether and dried to afford 162 mg (43%) of the title COMPOUND. LH NMR (300 MHz, DMSO-D6) 8 8.50 (m, 2H), 7.55-6. 95 (m, 4H), 6.40 and 6.17 (rotamers, 2s, 1H), 5.03 and 4.83 (rotamers, 2s, 2H), 3.71 and 3.67 (rotamers, 2s, 3H), 3.09 and 2.96 (rotamers, 2s, 3H). MS (ESI) INULE : 346.1662 (M+H) +.
The synthetic route of 709652-82-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AFFINIUM PHARMACEUTICALS, INC.; WO2004/52890; (2004); A1;,
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