Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19235-89-3, name is 4-Chloropyridine-2-carbonitrile. A new synthetic method of this compound is introduced below., HPLC of Formula: C6H3ClN2
Reference Example 111 2-Cyano-4-methylthiopyridine 4-Chloro-2-cyanopyridine (2.18 g, 15.7 mmol) and sodium thiomethoxide (2.20 g, 31.4 mmol) were dissolved in THF (100 ml), and the mixture was refluxed for 2 hrs.. The reaction mixture was combined with ethyl acetate and water.. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate.. The solvent was evaporated to give the titled compound (2.36 g, 99 %) as pale yellow crystals.1H-NMR (CDCl3) delta: 2.53 (3H, s), 7.25-7.27 (1H, m), 7.45(1H, s), 8.46 (1H, d, J = 5.3 Hz). IR(KBr): 2233, 1574, 1537, 1462, 1386, 1292, 1099, 987, 962, 844 cm-1.
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Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1424336; (2004); A1;,
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