Application of 1201676-03-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1201676-03-0, name is 4,6-Dichloro-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one, molecular formula is C7H4Cl2N2O, molecular weight is 203.03, as common compound, the synthetic route is as follows.
A solution of 4,6-dichloro-2H,3H-pyrrolo[3,4-c]pyridin-l-one (1.0 g, 4.9 mmol, 1 eq.), 2- cyclopropyl-4,4,5,5-tetramethyl-l,3,2-dioxaborolane (2.0 mL, 11 mmol, 2.2 eq.), [1,1′- bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with DCM (0.80 g, 1.0 mmol, 0.2 eq.) and potassium carbonate (3.4 g, 25 mmol, 5 eq.) in dioxane-water (10: 1 v/v, 15 mL) was degassed and heated at 80 C for 16 hours. After cooling the mixture, it was diluted with water and extracted with 15% isopropanol in chloroform (3x). The combined organic layers were dried, filtered and concentrated. The product was purified chromatography B to afford the title compound (0.44 g, 42%) as a white solid.
Statistics shows that 1201676-03-0 is playing an increasingly important role. we look forward to future research findings about 4,6-Dichloro-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one.
Reference:
Patent; NURIX THERAPEUTICS, INC.; BARSANTI, Paul A.; BENCE, Neil F.; GOSLING, Jennifa; SAHA, Anjanabha; TAHERBHOY, Asad M.; ZAPF, Christoph W.; BOYLE, Kathleen; CARDOZO, Mario; MIHALIC, Jeffrey; LAWRENZ, Morgan; GALLOP, Mark; BRUFFEY, Jilliane; CUMMINS, Thomas; ROBBINS, Daniel; TANAKA, Hiroko; WANG, Chenbo; COHEN, Frederick; PALMER, Wylie; SANDS, Arthur T.; SHUNATONA, Hunter; (968 pag.)WO2019/148005; (2019); A1;,
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